The Importance Of Biology - 753 Words

Background Survey/Significance Living cells maintain their life by using epigenetic transcriptional memory to respond to their changing environmental stimuli (D’Urso and Brickner, 2014). Epigenetic transcriptional memory phenomenon causes changes in chromatin structure, allowing cells to have a rapid transcriptional response to an environmental stimulus that they have previously experienced (D’Urso and Brickner, 2016). Transcriptional memory is prominent in eukaryotic cells because multicellular eukaryotes have vast, complicated genomes that are organized into numerous chromosomes, compared to smaller prokaryotic genomes. Eukaryotes regulate gene expression by either limiting the amount of mRNA created from a gene or post-transcriptional†¦show more content†¦These experimental results can be connected to the transcriptional memory in yeast, which usually likes to use glucose as its main source of energy. However, when placed in galactose, the yeast must transcr ibe a gene called Gal1 that codes for galactokinase enzyme, which phosphorylates galactose into glucose. When this stress is reintroduced, the yeast strain that had previously transcribed the Gal1 gene is able to grow faster than strains that have not been introduced to galactose. Although these results reveal that these modifications make an impact on transcriptional memory, there is little research on what these modifications are. This research project focuses on modifying the 3rd and 4th histone tails and their impact on Gal1 transcriptional memory. By studying transcriptional memory, we can apply this memory mechanism into slowing down the process of cancer cell growth or induce the growth of healthy cells. Specific Aims/Hypothesis The first aim of this research project is to elicit mutations of the amino acids in the histone tails and create mutated yeast strains. This is done to determine how the chromatin packaging through mutations of the histone tails impacted Gal1 transcriptional long and short-term memory. The second aim is to create a chimeric Gal1/mCherry/neo exogenous DNA strand and insert it into the yeast genomes to form genetic modified yeast colonies (wild type,Show MoreRelatedImportance Of Cell Biology1122 Words   |  5 Pagesand a half now, I have entered a more intensive research environment by working as research associate in the LaBarge Lab with the intention of working towards curing breast cancer. My regular routine runs the gamut of activities expected in a cell biology lab: feeding, passaging, expanding, and freezing cell strains grown in our lab; FACS sorting cells based on lineage specific surface markers; immunofluorescence imaging; gene expression analysis. As a research associate, I also make stock solutionsRead MoreThe Importance Of Cells In Biology1000 Words   |  4 PagesTHE Cellular process is bad for health are made and ran by the expression of more than one genes in a network of same complicated signaling pathways, staying of many physical and functional interactions.not like the stable genome structure, the moving represents a gigantic challenge for the quantitative mapping out protein interactions . The circuit includes nuclear receptors, dna binding proteins and processes. Genome variation includes somatic and inherited mutations,Each human cellRead MoreThe Importance Of Genes In Biology768 Words   |  4 Pages1. DNA, or deoxyribonucleic acid, is considered a genetic material that organisms inherit from their parents after reproduction (Simon, E.J. (2017). Biology: The Core (2nd Edition). Retrieved from https://etext.pearson.com). This acid, DNA, is what instructs RNA, or ribonucleic acid, to produce proteins. 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Therefore, kisspeptin stimulates GNRH secretion through GNRH neuronsRead MoreThe Importance of the Biology/Society Dualism to the Gendered Body2250 Words   |  9 PagesThe Importance of the Biology/Society Dualism to the Gendered Body The body has played an important part in sociology to explain the differences between the two sexes, and why these differences exist. A lot of social debate is about the relationship between the biological and the social. At one end of the debate there are those who see activities such as sexual behaviour entirely based on biology, they are called biological determinists who argue that there is biological Read MoreThe Effect Of Data Analysis On The Importance Of Cells In Biology853 Words   |  4 PagesNow according to micronucleus formation was marginally reduced after NA supplementation and can be shown in fig 18 suggesting a slightly better preservation on overall genomic stability. The difference in those two cells is because of NAD+ level available in stimulated phase, which overall constrains the repair activity of proliferating cells. So based on the overall data analysis further usage of NA could be conceivable as we showed in the application of lower concentration of NA of 15  µM NAD+ precursorRead MoreImportance Of Synthetic Biology : High-Technology Perishable Designs952 Words   |  4 PagesHigh-tech Perishable Designs - Synthetic Biology Our journey of moving from homogenous to heterogeneous, from bio-mimicry to synthetic biology, of rationally engineer microorganisms dates back to 1990s. Synthetic biology—unlike chemistry—is involved in the technical alteration of animate nature. 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